diff --git a/CHANGELOG.md b/CHANGELOG.md
index cdf43a69..32e95b5f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,8 @@ Note: In this file, do not use the hard wrap in the middle of a sentence for com
 
 ## [Unreleased]
 
+- Update `uv@latest` to 0.9.21.
+
 ## [2.65.9] - 2025-12-30
 
 - Update `cargo-llvm-cov@latest` to 0.6.22.
diff --git a/manifests/uv.json b/manifests/uv.json
index eb397e69..cd351fea 100644
--- a/manifests/uv.json
+++ b/manifests/uv.json
@@ -40,10 +40,48 @@
   },
   "license_markdown": "[Apache-2.0](https://github.com/astral-sh/uv/blob/main/LICENSE-APACHE) OR [MIT](https://github.com/astral-sh/uv/blob/main/LICENSE-MIT)",
   "latest": {
-    "version": "0.9.20"
+    "version": "0.9.21"
   },
   "0.9": {
-    "version": "0.9.20"
+    "version": "0.9.21"
+  },
+  "0.9.21": {
+    "x86_64_linux_musl": {
+      "etag": "0x8DE47BE93AD9727",
+      "checksum": "7abc29b3a06a99fb23564400fe884f5798a1786dc2ca05b6e0f70c53de748ab2"
+    },
+    "x86_64_macos": {
+      "etag": "0x8DE47BE9331C680",
+      "checksum": "26390da48bd55e21ab62451a80ad240ef6df10d4c48ec199cbb34c18b4288983"
+    },
+    "x86_64_windows": {
+      "etag": "0x8DE47BE93431824",
+      "checksum": "d27952e73183ef8f6ee8c2a50cf8b3f2e08e01b6a9279a00a85cb261ea8d8337"
+    },
+    "aarch64_linux_musl": {
+      "etag": "0x8DE47BE90FDFFD3",
+      "checksum": "03a49fb609888032dbc3be9fd114b50fc9bce8b73b3df319746ae08d1fbdea83"
+    },
+    "aarch64_macos": {
+      "etag": "0x8DE47BE9074A9C8",
+      "checksum": "473977236ef8ac5937c80de08a3599cb6ed6021d0e015e10f88076767877a153"
+    },
+    "aarch64_windows": {
+      "etag": "0x8DE47BE90ADC90E",
+      "checksum": "54f66a44108b1b68583c9da0a515195d011189874ec9547710c032801726e042"
+    },
+    "powerpc64le_linux_gnu": {
+      "etag": "0x8DE47BE9298F19B",
+      "checksum": "3ede0329f67f5db37914b5dfd6014c414d27e1bf0153dab8d5cc2e066da034dc"
+    },
+    "riscv64_linux_gnu": {
+      "etag": "0x8DE47BE92B9E90B",
+      "checksum": "3b7b070afd9c7be5a6364f081081cf9fec2160b53eba46cad27304b8b158e4ab"
+    },
+    "s390x_linux_gnu": {
+      "etag": "0x8DE47BE92CC98B3",
+      "checksum": "34bd75d67a5819c9f796a78b1ec9ebd48021d87d2391b4cf282249c4d026f145"
+    }
   },
   "0.9.20": {
     "x86_64_linux_musl": {